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It was recently found that coffee drinkers live longer,上海龙凤论坛Arely, The researchers showed the patients two videos simultaneously, took a statistical deep dive into 5087 randomized controlled trials With the help of a computer program Carlisle looked for a specific type of anomaly: nonrandom assignment of volunteers to different treatments when the trial had claimed the assignments were random This can skew a trial’s results—for example if many more elderly people are assigned to a control group while younger ones get an experimental treatment the new drug may look like it has fewer side effects because the people getting it are healthier Across eight journals Carlisle analyzed how certain features of the volunteers—such as their height weight and age—were spread across the treatments tested If he didn’t see certain patterns—if the distribution was too perfect or too far off—he suspected the assignments were not truly random whether because of scientific misconduct or honest error Roughly 2% of the papers he ran through his program fell into this questionable category But “Although my analysis throws up questions it doesn’t necessarily throw up answers” Carlisle says For that the journals needed to step in Within days of Carlisle’s report NEJM had homed in on 11 of its papers with the loudest alarm bells Six turned out to contain mistakes In five cases the issue was a mixup of statistical terms—for example writing “standard deviation” which measures variability across data in place of “standard error” a type of standard deviation that depends on sample size But in the sixth a large clinical trial in Spain published in 2013 which had reported that a Mediterranean diet could prevent heart disease in people at risk deeper problems surfaced “It turned out when we contacted the investigators they had already been working on it they had seen the same thing we had and been concerned” says NEJM Editor-in-Chief Jeffrey Drazen in Waltham Massachusetts Nearly 7500 people all over Spain had enrolled in the trial as long as 15 years ago so tracking down what might have gone wrong was no easy feat A months-long inquiry by the Spanish researchers and NEJM staff uncovered that up to 1588 people in the trial hadn’t been properly randomized: Some were assigned to the same diet as someone else in their household (a common feature of diet studies but not reported in the original paper) Others who lived in a rural area were assigned to different diets based on the clinic closest to them—for example one group had to pick up a liter of olive oil each week “The investigator realized he couldn’t get people to travel as far as they needed so he made his study ‘cluster randomized’” by clinic rather than by individual Drazen says The authors reanalyzed their data without those 1588 participants and found that despite the missteps the conclusion held: Nuts olive oil and fatty fish remained a net positive on heart health though the conclusions came with somewhat less statistical oomph than in the original paper And what of the other seven journals targeted by Carlisle last year Science contacted all of them to ask whether they too had investigated The editor-in-chief of one the Canadian Journal of Anesthesia said an inquiry is in progress but running slowly because of limited resources At another journal Anesthesiology editors had looked over the papers and found no reason to retract any of them The other journals either didn’t respond or have chosen not to investigate Some noted that Carlisle’s paper had come under criticism when it was published in part because its methods assumed certain variables like height and weight are unrelated (Carlisle agrees this was a limitation and says not every paper he identified necessarily contains errors) Carlisle pinpointed eight papers at his own journal Anaesthesia worth probing “We wrote to the authors and got two responses … the others have not responded” he says In one of those two a correction was published this week though it didn’t impact the paper’s conclusions; in the second the authors said they no longer had the patient data the journal was requesting For the six whose answer was radio silence Carlisle isn’t sure how hard to push “How far do you drill into it” he wonders especially when the time and money to do so are scarce Although most of the errors so far are minor ones Carlisle wonders whether they’re a harbinger of statistical problems in parts of papers he didn’t examine such as the all-important results section Drazen was unsettled enough by what his own journal found to give his manuscript editors a statistics course and implement extra scrutiny of statistics in accepted papers By Lesley Wroughton and Michelle Nichols WASHINGTON/UNITED NATIONS (Reuters) – The United States withdrew from a "hypocritical and self-serving" United Nations Human Rights Council on Tuesday over what it called chronic bias against Israel and a lack of reform a move activists warned would make advancing human rights globally even more difficult Standing with US Secretary of State Mike Pompeo at the State Department US Ambassador to the United Nations Nikki Haley slammed Russia China Cuba and Egypt for thwarting US efforts to reform the council She also criticized countries which shared US values and encouraged Washington to remain but "were unwilling to seriously challenge the status quo" Washington’s withdrawal is the latest US rejection of multilateral engagement after it pulled out of the Paris climate agreement and the 2015 Iran nuclear deal It also comes as the United States faces intense criticism for detaining children separated from their immigrant parents at the US-Mexico border UN human rights chief Zeid Ra’ad al-Hussein on Monday called on Washington to halt its "unconscionable" policy "Look at the council membership and you see an appalling disrespect for the most basic rights" said Haley citing Venezuela China Cuba and Democratic Republic of Congo She did not mention Saudi Arabia which rights groups pushed to be suspended in 2016 over killings of civilians in the Yemen war Among reforms the United States had pushed for was to make it easier to kick out member states with egregious rights records Currently a two-thirds majority vote by the 193-member UN General Assembly is needed to suspend a member state Haley also said the "disproportionate focus and unending hostility towards Israel is clear proof that the council is motivated by political bias not by human rights" Israeli Prime Minister Benjamin Netanyahu welcomed the US decision The United States has long shielded its ally Israel at the United Nations In citing what it says is bias against Israel the administration of President Donald Trump could further fuel Palestinian arguments that Washington cannot be a neutral mediator as it prepares to roll out a Middle East peace plan Washington also relocated its embassy to Jerusalem after recognising it as the capital of Israel reversing decades of US policy The United States is half-way through a three-year term on the 47-member Geneva-based body and the Trump administration had long threatened to quit if it was not overhauled ‘MISGUIDED POLICY’ Rights groups have criticized the Trump administration for not making human rights a priority in its foreign policy Critics say this sends a message that the administration turns a blind eye to human rights abuses in some parts of the world "Given the state of human rights in today’s world the US should be stepping up not stepping back" Zeid said after Haley announced the US withdrawal Reuters reported last week that talks on reforming the council had failed to meet Washington’s demands suggesting the Trump administration would quit "The Human Rights Council enables abuses by absolving wrongdoers through silence and falsely condemning those that committed no offence" Pompeo said Diplomats have said the US withdrawal could bolster countries such as Cuba Russia Egypt and Pakistan which resist what they see as UN interference in sovereign issues Haley said the withdrawal "is not a retreat from our human rights commitments" Twelve rights and aid groups including Human Rights First Save the Children and CARE warned Pompeo the US withdrawal would "make it more difficult to advance human rights priorities and aid victims of abuse around the world" Jamil Dakwar director of the American Civil Liberties Union’s Human Rights Program said Trump’s "misguided policy of isolationism only harms American interests" The EU said Washington’s decision "risks undermining the role of the US as a champion and supporter of democracy on the world stage" British Foreign Secretary Boris Johnson said it was regrettable and that the council was the "best tool the international community has to address impunity" FIRST MEMBER TO WITHDRAW The Human Rights Council meets three times a year to examine human rights violations worldwide It has mandated independent investigators to look at situations including Syria North Korea Myanmar and South Sudan Its resolutions are not legally binding but carry moral authority When the Council was created in 2006 US President George W Bush’s administration shunned the body Under President Barack Obama the United States was elected for a maximum two consecutive terms on the council by the UN General Assembly After a year off Washington was re-elected in 2016 for its current third term UN officials said the United States would be the first member to withdraw from the council Haley said a year ago that Washington was reviewing its membership The body has a permanent standing agenda item on suspected violations committed by Israel in the occupied Palestinian territories that Washington wanted removed The council last month voted to probe killings in Gaza and accused Israel of using excessive force The United States and Australia cast the only "no" votes "The UN Human Rights Council has played an important role in such countries as North Korea Syria Myanmar and South Sudan but all Trump seems to care about is defending Israel" said Human Rights Watch executive director Ken Roth (Additional reporting by Steve Holland in Washington Stephanie Nebehay in Geneva and Ori Lewis in Jerusalem; Writing by Michelle Nichols Editing by Yara Bayoumy and James Dalgleish) This story has not been edited by Firstpost staff and is generated by auto-feedCynthia F ? FBI data shows nearly one-third of all mass shootings in the U. The Goans kept East Bengal on their toes and almost went ahead again in the 84th minute when Nicholas fired in a long- range left-footed shot but he shot directly to K Mirshad. It is wrong to make such statements and is not in the best interest of the country. The local police installed millions of dollars of surveillance equipment in residential neighborhoods, Don’t worry though. however, https://t.

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